When 4 year old Amanda McCready disappears from her home and the police make little headway in solving the case, the girl's aunt, Beatrice McCready hires two private detectives, Patrick Kenzie and Angie Gennaro. The detectives freely admit that they have little experience with this type of case, but the family wants them for two reasons - they're not cops and they know the tough neighborhood in which they all live. As the case progresses, Kenzie and Gennaro face drug dealers, gangs and pedophiles. When they are about to solve the case, they are faced with a moral dilemma that tears them apart.
Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.
The Driver specializes in driving getaway cars for robberies. His exceptional talent has prevented him from being caught yet. After another successful flight from the police a self-assured detective makes it his primary goal to catch the Driver. He promises pardons to a gang if they help to convict him in a set-up robbery. The Driver seeks help from The Player to mislead the detective.
Two Los Angeles homicide detectives are dispatched to a northern town where the sun doesn't set to investigate the methodical murder of a local teen.
Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.
Private Investigator Philip Marlowe is hired by wealthy General Sternwood regarding a matter involving his youngest daughter Carmen. Before the complex case is over, Marlowe sees murder, blackmail, deception, and what might be love.
In the smog-choked dystopian Los Angeles of 2019, blade runner Rick Deckard is called out of retirement to terminate a quartet of replicants who have escaped to Earth seeking their creator for a way to extend their short life spans.
Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.