Three old high school friends meet in a Michigan motel room to dissect painful memories from their past.
Events over the course of one traumatic night in Paris unfold in reverse-chronological order as the beautiful Alex is brutally raped and beaten by a stranger in the underpass. Her boyfriend and ex-lover take matters into their own hands by hiring two criminals to help them find the rapist so that they can exact revenge. A simultaneously beautiful and terrible examination of the destructive nature of cause and effect, and how time destroys everything.
Undercover cop Jim Raynor (Jason Patric) is a seasoned veteran. His partner, Kristen Cates (Jennifer Jason Leigh), is lacking in experience, but he thinks she's tough enough to work his next case with him: a deep cover assignment to bring down the notoriously hard-to-capture drug lord Gaines (Gregg Allman). While their relationship turns romantic during the assignment, they also turn into junkies, and will have to battle their own addictions if they want to bring down Gaines once and for all.
After 20 years abroad, Mark Renton returns to Scotland and reunites with his old friends Sick Boy, Spud and Begbie.
Ben Stiller plays comedy writer Jerry Stahl, whose $6000-a-week heroin habit had him taking his infant daughter along on his drug runs and doing smack during TV script conferences. Departing detox, Stahl explores memories with survivor Kitty, who listens patiently to Stahl's flashback. Other women in Stahl's life are his British wife Sandra and his agent Vola.
Mark Renton, deeply immersed in the Edinburgh drug scene, tries to clean up and get out, despite the allure of the drugs and influence of friends.
While investigating a young nun's rape, a corrupt New York City police detective, with a serious drug and gambling addiction, tries to change his ways and find forgiveness.
When 4 year old Amanda McCready disappears from her home and the police make little headway in solving the case, the girl's aunt, Beatrice McCready hires two private detectives, Patrick Kenzie and Angie Gennaro. The detectives freely admit that they have little experience with this type of case, but the family wants them for two reasons - they're not cops and they know the tough neighborhood in which they all live. As the case progresses, Kenzie and Gennaro face drug dealers, gangs and pedophiles. When they are about to solve the case, they are faced with a moral dilemma that tears them apart.